A comprehensive survey of single amino-acid substitution mutations critical for RNA polymerase function published in Journal of Biology supports a proposed mechanism for polymerase action in which movement of the polymerase 'bridge helix' promotes transcriptional activity in cooperation with a critical substrate-interaction domain, the 'trigger loop'. © 2008 BioMed Central Ltd.
CITATION STYLE
Kaplan, C. D., & Kornberg, R. D. (2008). A bridge to transcription by RNA polymerase. Journal of Biology. https://doi.org/10.1186/jbiol99
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