Transcriptional stimulatory and repressive functions of histone H2B ubiquitin ligase

Abstract

Histone H2B ubiquitylation is involved in regulation of transcription and other DNA transacting processes. It is performed by a RING finger-containing ubiquitin ligase, Bre1, which is conserved from yeast to humans. Recent studies have implicated both transcriptional stimulatory and repressive functions of histone H2B ubiquitin ligase at the same or different genes as discussed here. © 2013 Landes Bioscience.