Sulbactam-containing β-lactamase inhibitor combinations

Abstract

Sulbactam irreversibly inhibits the hydrolytic activity of β-lactamases. This compound is commercially available in combination with either ampicillin or cefoperazone. In each instance, the activity of the partner antibiotic against β-lactamase-producing bacteria is restored. One of the particular advantages of using sulbactam-containing combinations is that sulbactam itself has inherent activity against some Acinetobacter baumannii. Sulbactam combinations have not demonstrated strong selective pressures for extended-spectrum β-lactamase-producing Enterobacteriaceae and vancomycin-resistant enterococci. In contrast to clavulanate, sulbactam does not induce classI (Ampc) chromosomal β-lactamases in Enterobacteriaceae. © 2008 The Author Journal Compilation © 2008 European Society of Clinical Microbiology and Infectious Diseases.