Role of HERP and a HERP-related protein in HRD1-dependent protein degradation at the endoplasmic reticulum

Abstract

Background: HERP1 has been implicated in ERAD with unknown mechanism. Results: HERP1 and newly identified HERP2 are integral components of the HRD1 complex, facilitating retrotranslocation by recruiting DERL2 to HRD1. Conclusion: HERPs are partially redundant, required for HRD1-mediated retrotranslocation. Significance: HERP1 and HERP2 are essential adaptors between HRD1 and DERL2 that help organizing a functional retrotranslocation complex in HRD1-mediated ERAD. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..