Prevalence of depression among children and adolescents with type 2 diabetes: a systematic review and meta analysis

Abstract

Background: The prevalence of depression in children and adolescents with type 2 diabetes (T2D) is a clinical, public and social problem. To evaluate the characteristic of depression in children and adolescents, a systematic review and meta-analysis was performed to investigate the association between T2D and prevalence of depression among children and adolescents. Methods: Retrospective study and prospective study on the prevalence of depression in children with T2D were searched by computer from databases such as PubMed, EMBASE, the Cochrane Library, CNKI, VIP and Wanfang Data. The retrieval time was April 2022. According to inclusion and exclusion criteria, the literature was screened, and data were extracted. Stata 14 software was used, and meta-analysis was performed using double arcsine method to calculate the prevalence and the 95% confidence interval. Results: A total of 4,039 children or adolescents with T2D were enrolled in the study. After retrieving the literature database, finally, 8 studies were included. Meta analysis showed that the overall prevalence of depression in T2D was 19.9% (95% CI: 14.3–26.2%), and there was significant heterogeneity (I2=94.056%, P=0.000). Discussion: The results of this study indicate that children with T2D have higher prevalence of depression, which is of clinical significance for screening and prevention of disease.