Cutaneous hyperpigmentation secondary to vitamin B12 deficiency in an infant

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Abstract

Cutaneous hyperpigmentation is a rare clinical feature of vitamin B12 (cobalamin) deficiency. The cause is unknown and there are different hypothesis about the pathogenesis of the hyperpigmentation. We report the case of an 8-month-old girl, with history of neuromadurative delay, hypotonia, anemia and neutropenia, who was referred to our Service by brownish hyperpigmentation on her hands and feet of 3 months of evolution. Based on the clinical suspicion of vitamin B12 deficiency, we performed a laboratory dosage that showed decreased levels of cobalamin, reason for which replacement therapy was indicated. It highlights the importance of the presumption of vitamin B12 deficiency as a cause of cutaneous hyperpigmentation and its rapid resolution after the establishment of the appropriate treatment.

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Viada Pelaez, M. C., Buján, M. M., & Cervini, A. B. (2020). Cutaneous hyperpigmentation secondary to vitamin B12 deficiency in an infant. Archivos Argentinos de Pediatria, 118(1), E63–E66. https://doi.org/10.5546/AAP.2020.E63

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