Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reactionand desulfanylation

Abstract

Thirteen difluoromethyl-containing pseudopeptides were synthesized by Ugi reaction using the novel building block 2,2-difluoro-2- (phenylthio)acetic acid (2) as one component, followed by removal of the phenylsulfanyl protecting group in the presence of tributyltin hydride and azobisisobutyronitrile. © 2011 Wu et al.