Photochemical Multicomponent Synthesis of Six-Membered Heterocycles

Abstract

Despite the efficient progress achieved in the synthesis of heterocyclic compounds, accessing these molecules by combining both visible lights induced radical chemistry and multicomponent reactions is extremely demanding yet challenging. Recognizing the significant features associated with oxygen- and nitrogen-containing heterocyclic compounds, the search for these attractive molecules in nature and developing new synthetic strategies for synthesizing these molecules remain interesting domain for synthetic chemists. In this mini-review article, we aim to demonstrate a transitory outline of the recent development achieved in the synthesis of six-membered heterocycles having oxygen and nitrogen as the major heteroatoms as well as six-membered heterocycle containing spirooxindole molecules based on visible-light-induced photochemical multicomponent reactions strategies. Besides addressing the key success of the reaction design and product developments in this promising area, we have also emphasized the major shortcomings and challenges associated with the reaction discovery in order to stimulate further succeeding investigations.