0568 EFFECT OF VARYING DIET INTENSITIES ON WEIGHT LOSS INTERVENTION FOR OSA

Abstract

Introduction: Excess body weight is greatest risk factor for obstructive sleep apnea (OSA) and weight loss has been shown to be effective but few randomized controlled trials have compared different weight loss interventions. We compared low calorie diet (LCD), very low calorie diet (VLCD) and usual care groups that coincided with initiation of treatment for OSA. Methods: Subjects were enrolled from a sleep clinic with the majority being newly diagnosed with OSA and just starting on positive airway pressure therapy. Criteria included BMI 30‐50 kg/m2, AHI>5 and age 21‐75 years. Patients were enrolled in a 3:3:2 allocation for both diets versus usual care. LCD 1200‐1500 kcal/day, VLCD 500‐800 kcal/ day and usual care included weight loss encouragement. Repeat sleep study testing was performed at 3 months. Results: The UC group lost an average of 4.9+/=7.4 lbs, the LCD group lost 21.1+/=13.3 lbs and the VLCD group lost 38.6+/=12.6 lbs at 3 months which corresponded to a 2.1, 8.7 and 14.3% decrease in weight with significant difference between all groups (p<0.05). the average AHI decreased by 15.7+/=15.7 in the UC group (p=0.355), 17+/=10.8 in the LCD group (p=0.024) and 6.3=/+5.6 in the VLCD group (p=0.015). Conclusion: There was a clinically and statistically significant decrease in body weight and AHI that varied according to weight loss group with the greatest weight loss and largest decrease in AHI occurring in the VLCD compared to the LCD diet and usual care group. Despite the significant dietary restrictions of a very low calorie diet, many participants were able to comply with the diet and lose significant weight. Repeat testing at 6 months is planned as well as enrollment of additional research participants.