PGRS domain structures: Doomed to sail the mycomembrane

Abstract

AThUe:imPlpeaascetcoofnafirrtmifitchiaatlainlltheellaigdeinngcleev(eAlsIa)rineruepnrdeesresnttaendcdoinrrgebctiloyl:ogical processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-Terminus.