Intraperitoneal Injection of cinnamon extract (Cinnamomum zeylanicum) on Passive Avoidance Learning in Rats with Streptozotocin-induced Alzheimers Disease

Abstract

Alzheimer's disease is one of the most prevalent brain neurodegenerative diseases, in which neurons are destroyed specially in the areas related to cognitive activities. In the past, many drug therapies have been introduced for Alzheimer's disease that despite significant developments, they were not succeeded completely. In the present research, the effects of extract of cinnamon (Cinnamomum zeylanicum) were studied on consolidation phase of memory in Streptozotocin male wistar rats model of Alzheimer's disease. Total 30 male wistar rats were divided into five groups. One group kept intact, given no injection whereas groups were treated with dimethyl sulfoxide (DMSO), dimethyl sulfoxide and Streptozotocin, Streptozotocin (STZ) as intracerebral ventricular and cinnamon extract through intraperitoneal. To assess learning and memory in rats, the passive avoidance learning test was performed. Intracerebroventicular Streptozotocin injection caused severe injuries to learning capacity and memory of rats, whereas the group received C. zeylanicumextract was found to improve such impairments.