Distinct Cleavage Products of Nuclear Autoantigens in Apoptosis and Necrosis: Implications for Autoimmunity

Abstract

Introduction The Multiple Faces of Cell Death Apoptosis Necrosis Caspase-independent Cell Death Autoantigen Cleavage in Apoptosis Autoantigen Cleavage in Non-apoptotic Cell Death Autoantigen Cleavage during Primary Necrosis Autoantigen Cleavage during Secondary Necrosis Autoantigen Cleavage during Caspase-independent Cell Death Implications of Autoantigen Cleavage for Autoimmunity Immunogenicity of Apoptotic Cells Immunogenicity of Necrotic Cells Apoptosis, Necrosis and Immunity to Intracellular Antigens Modified Autoantigens and Defective Phagocytic Function Conclusions Acknowledgments References.