Complete genome sequence of cell culture-attenuated guinea pig cytomegalovirus cloned as an infectious bacterial artificial chromosome

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Abstract

The complete genome sequence of attenuated guinea pig cytomegalovirus cloned as bacterial artificial chromosome N13R10 was determined. Comparison to pathogenic salivary gland-derived virus revealed 13 differences, 1 of which disrupted overlapping open reading frames encoding GP129 and GP130. Attenuation of N13R10 may arise from an inability to express GP129 and/or GP130.

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Yang, D., Alam, Z., Cui, X., Chen, M., Sherrod, C. J., McVoy, M. A., … Dittmer, D. P. (2014). Complete genome sequence of cell culture-attenuated guinea pig cytomegalovirus cloned as an infectious bacterial artificial chromosome. Genome Announcements, 2(5). https://doi.org/10.1128/genomeA.00928-14

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