Pyrinodemins B - D, potent cytotoxic bis-pyridine alkaloids from marine sponge Amphimedon sp.

Abstract

New bis-pyridine alkaloids, pyrinodemins B - D (1 - 3), have been isolated together with pyrinodemin A (4) and related 3-alkyl pyridine alkaloids 5 - 8 from the Okinawan marine sponge Amphimedon sp. and the structures were elucidated from spectroscopic data. Pyrinodemins B - D (1 - 3) showed potent cytotoxicity, while compounds 5 - 8 exhibited antimicrobial activity.