The inhibitor of human bladder epithelial cancer cells from Indonesian marine sponge of Petrosia sp.

Abstract

The investigation of bioactive compound from Indonesian marine sponge Petrosia sp. has been done on February 2019. The bioactive compound isolated based on bioassay-guide dseparation with several steps of chromatography. The bioactive compound known as C16H25NS determined by LCMS-ESI with molecular weight [M+H] + 263.42 m/z. The FTIR spectrumshowd that the bioactive metabolite has alkane skeleton of hydrocarbonat 2982.58 cm-1andisonitrile functional group at 2115 cm-1. The result of NMR interpretation showed that the bioactive compound know as 4-amorphene with decalin as hydrocarbon skeleton with additional isonitrile moiety. The rate of viability show scytotoxic against NBT-T2 cell.