Computational analysis of axonal transport: A novel assessment of neurotoxicity, neuronal development and functions

Abstract

Axonal transport plays a crucial role in neuronal morphogenesis, survival and function. Despite its importance, however, the molecular mechanisms of axonal transport remain mostly unknown because a simple and quantitative assay system for monitoring this cellular process has been lacking. In order to better characterize the mechanisms involved in axonal transport, we formulate a novel computer-assisted monitoring system of axonal transport. Potential uses of this system and implications for future studies will be discussed. © 2012 by the authors; licensee MDPI, Basel, Switzerland.