Protection against enteric disease caused by Escherichia coli-a model for vaccination with a virulence determinant?

Abstract

ALTHOUGH vaccination has assisted the control of many bacterial diseases, parenteral vaccination against enteric disease is not as satisfactory as we could wish1. This is attributable to incomplete knowledge of both the pathogenesis of intestinal infections and the protective immune responses of the alimentary tract, with the result that vaccine development has been largely empirical. New knowledge of the specific determinants of microbial pathogenicity2 provides a sounder basis for the development of effective vaccines and the following report is an example of this approach to disease control. © 1973 Nature Publishing Group.