S131. TOWARDS SPATIAL ANALYSIS OF DIGITAL PHENOTYPING SMARTPHONE ACTIVITY IN SCHIZOPHRENIA

Abstract

Background: While it is clear that social determinants of health impact those with schizophrenia and often may impair access to treatment or support - to date accurate reporting of how patients interact with their environments has been challenging. Utilizing digital phenotyping via smartphone apps, it is now possible to study the correlations between patients; real time location and symptoms as well as quantity the environments patients interact with on a minute by minute time scale. Methods: Utilizing the open source Beiwe smartphone platform developed by Dr. Onnela at the Harvard School of Public Health and the open source LAMP smartphone platform developed by our group - we have to date captured smartphone data on location (GPS), sociability (anonymized call/ text logs), physical activity (accelerometer), symptoms (phone surveys), and cognition (phone games) from 25 patents. Patients are asked to install these apps and then use them for 90 days. Using the ESRI ArcGIS 10.3 geospatial analysis platform, we are able to compare the locations of patients against a variety of U.S. census collected information including spaces that are considered 'environmental justice areas' where the government has raised concern about lack of access to public services, support, green spaces, and other factors. Results: The amount of GPS data varies greatly by patient with a mean of 408,291 but standard deviation of 301,680. For results to date, the total time that patients with schizophrenia spent in environmental justice areas compared to non-environment justice area was 60% with a standard deviation with a standard deviation of 42.3%. With ongoing data collection, we expect the standard deviations will reduce. In examining psychotics symptoms that patients self-report to the smartphone apps, preliminary analysis suggests there is an association between environmental justice areas and more severe self-reported symptoms. Discussion: Our results suggest that it is feasible to collect environmental and symptom data via smartphones in patients with schizophrenia. Our preliminary results that patients spend more time in environmental justice areas suggests that those with schizophrenia may have less access to spaces conducive to recovery. Further data collection and analysis from this work may offer quantification of the potential impact of the environment and produce the necessary data to lobby for specific change and improved services for those with schizophrenia.