Phytochemical Characterization of Ethanolic Extracts of the Leaves of Zanthoxylum Caribaeum Lam and Evaluation of Antimicrobial Activity Against Burkholderia Glumae

Abstract

Phytochemical analysis of the leaf extract of Zanthoxylum caribaeum Lam (Family Rutaceae) collected in the La Garita district, Municipality of Los Patios in Norte de Santander, Colombia, is reported. Ethanolic extracts by simple maceration were concentrated at reduced pressure. Secondary metabolites found in preliminary identification demonstrated the presence of of alkaloids, tannins, carotenoids, anthocyanins, coumarins, cardiotonics, flavonoids, quinones, saponins, sesquiterpen-lactones, and triterpenoids. Gas chromatography mass spectrometry analysis identified the presence of ten compounds, with a-trans-farnesene (33.5%) as the main constituent, followed by trans-a-caryophyllene (28.1%), S-cadinene (9.7%), caryophyllene oxide (8.3%) and a-muurolene (8.1%). Some of these compounds have been reported with biological properties such as antiparasitic, antimicrobial or cytotoxic, so Zanthoxylum caribaeum is a promising species in the Department of North Santander as a source of compounds chemicals with important biological activity.