Flow-assisted automated solid-phase microextraction for the determination of chloroethers in aqueous matrices

Abstract

In this study a method of flow-assisted automated solid-phase microextraction (FA-SPME) was developed for the determination of organic pollutants in aqueous samples. A CTC Combi-PAL autosampler coupled with gas chromatography–mass spectrometry (GC–MS) was used to automate the entire extraction process. In this method, the SPME fibre was exposed to 100 mL of sample in a direct immersion mode for 10 min. After exposure, the fibre was desorbed at the injection port of GC–MS. To demonstrate the applicability of FA-SPME, chloroethers were selected as model compounds. Good linear correlation was found over a concentration range of 0.5–100 µg/L. The detection limits of the method were determined between 0.02 and 0.05 µg/L with the coefficients of determination (R2) from 0.9980 to 0.9996. The relative standard deviations (RSDs) of the FA-SPME for three sequential FA-SPME analyses were determined to be in the range between 1.2% and 6.2% (n = 3). The applicability of the method was assessed by means of recovery studies and satisfactory values for all compounds were obtained. This optimised method was used in the analysis of water and human urine samples to show the matrix effect on FA-SPME. This FA-SPME/GC–MS is substantially faster and suitable for the routine continuous flow-mode environmental monitoring applications.