The aryl hydrocarbon receptor and the gut–brain axis

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Abstract

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.

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Barroso, A., Mahler, J. V., Fonseca-Castro, P. H., & Quintana, F. J. (2021, February 1). The aryl hydrocarbon receptor and the gut–brain axis. Cellular and Molecular Immunology. Springer Nature. https://doi.org/10.1038/s41423-020-00585-5

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