Synthesis, spectroscopic characterization, crystal structure and pharmacological properties of some novel thiophene-thiourea core derivatives

Abstract

New series of chromeno2,3bpyridines, 28, have been obtained from 1,8diazabicyclo 5.4.0undec7ene catalyzed Friedländer reaction of 8allyl2aminochromone3 carboxaldehyde (1) with some carbonyl compounds containing a reactive αmethyl or methylene group namely 2acetylthiophene, 3acetylpyridine, 4chloroacetophenone, 4,6 diacetylresorcinol, acetylacetone, dibenzoyl methane and acetoacetanilide. Heteroannulated chromones, 1316, were prepared from Friedländer reaction of 1 with some cyclic α methylene ketones namely pyrazoline3,5dione, 5,5 and thiobarbituric acid. Structures of the newly synthesized compounds have been established from elemental analysis and spectroscopic data