Reversible siRNA-polymer conjugates by RAFT polymerization

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Abstract

A straightforward synthetic method to prepare pyridyl disulfide end functionalized poly(PEG acrylate) by RAFT polymerization for efficient and reversible conjugation to siRNA is described. © The Royal Society of Chemistry.

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Heredia, K. L., Nguyen, T. H., Chang, C. W., Bulmus, V., Davis, T. P., & Maynard, H. D. (2008). Reversible siRNA-polymer conjugates by RAFT polymerization. Chemical Communications, (28), 3245–3247. https://doi.org/10.1039/b804812f

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