ART outcome in HIV-infected patients

Abstract

Background: To assess assisted reproductive technique (ART) outcome in couples affected by human immunodeficiency virus (HIV). Methods: Intrau terine insemination (IUI), IVF and ICSI were performed in 85 couples affected by HIV between January 2000 and June 2005. Results: In 33 of the 85 couples, women were HIV positive - the clinical pregnancy rate (CPR) and cancellation rate (CR) after 34 IUI cycles were, respectively, 25 and 18%. The CPR after 26 IVF and 30 ICSI cycles were, respectively, 37.5 and 18.8% with CRs of 38.5 and 46.7%, respectively. In 38 couples, men were infected - the CPR and CR after 85 IUI cycles were, respectively, 14.7 and 20%; 62 ICSI cycles were performed leading to CPR of 23.4% with a CR of 25%. In 14 couples, the two partners were infected: none of the four IUI cycles carried out was successful (CR, 20%); the CPR and CR after 35 ICSI cycles were, respectively, 12.5% with 31%. All children born had a negative HIV test. Conclusion: In couples affected by HIV, an acceptable pregnancy rate wa s obtained. The worst results were obtained when both partners were infected. The CR was elevated among HIV-infected couples. © 2006 Oxford University Press.