Preparation of polyfunctional nitriles by the cyanation of functionalized organozinc halides with p-toluenesulfonyl cyanide

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Abstract

Various alkyl, alkenyl, akynyl, benzylic, aromatic or heterocyclic organozinc halides bearing functional groups such as an ester, a boronic ester, a cyanide, a halide or a trialkoxysilyl group react under mild conditions with p-toluenesulfonyl cyanide affording polyfunctional nitriles in 69-93 % yields. © 1993.

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Klement, I., Lennick, K., Tucker, C. E., & Knochel, P. (1993). Preparation of polyfunctional nitriles by the cyanation of functionalized organozinc halides with p-toluenesulfonyl cyanide. Tetrahedron Letters, 34(29), 4623–4626. https://doi.org/10.1016/S0040-4039(00)60640-8

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