Raistrickiones a−e from a highly productive strain of penicillium raistrickii generated through thermo change

12Citations
Citations of this article
32Readers
Mendeley users who have this article in their library.

Abstract

Three new diastereomers of polyketides (PKs), raistrickiones A−C (1–3), together with two new analogues, raistrickiones D and E (4 and 5), were isolated from a highly productive strain of Penicillium raistrickii, which was subjected to an experimental thermo-change strategy to tap its potential of producing new secondary metabolites. Metabolites 1 and 2 existed in a diastereomeric mixture in the crystal packing according to the X-ray data, and were laboriously separated by semi-preparative HPLC on a chiral column. The structures of 1–5 were determined on the basis of the detailed analyses of the spectroscopic data (UV, IR, HRESIMS, 1D, and 2D NMR), single-crystal X-ray diffractions, and comparison of the experimental and calculated electronic circular dichroism spectra. Compounds 1–5 represented the first case of 3,5-dihydroxy-4-methylbenzoyl derivatives of natural products. Compounds 1–5 exhibited moderate radical scavenging activities against 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH).

Cite

CITATION STYLE

APA

Liu, D. S., Rong, X. G., Kang, H. H., Ma, L. Y., Hamann, M. T., & Liu, W. Z. (2018). Raistrickiones a−e from a highly productive strain of penicillium raistrickii generated through thermo change. Marine Drugs, 16(6). https://doi.org/10.3390/md16060213

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free