Studies on Ocimum basilicum mucilage based solid dispersions of indomethacin for enhancement of dissolution rate

Abstract

The main aim of this study was to enhance the dissolution rate of BCS class II drug Indomethacin (IND) by solid dispersion (SD) techniques using Ocimum basilicum mucilage (OBM) as a carrier. Solid dispersions of indomethacin were prepared by using Ocimum basilicum mucilage by four different methods. Effect of methods of preparation on dissolution rate was studied. It was found that the dissolution rate of IND from its SD was dependent on the method of preparation of solid dispersions. Dissolution study revealed that the physical mixture and kneading method were convenient and effective methods for dissolution enhancement of poorly water soluble drug IND, among various methods of preparation of SD. The prepared SD’s were characterized by FTIR, Differential Scanning Calorimetry, and X-ray diffraction studies. From the study we conclude that OBM could be used as a potential carrier in enhancing the dissolution rate and ultimately bioavailability of IND.