SP664DIETARY ADVANCED GLYCATION END PRODUCTS RESTRICTION EFFECTS ON INTESTINAL BACTERIAL FLORA AND MICROINFLAMMATION STATE IN MAINTENANCE HEMODIALYSIS PATIENTS

Abstract

INTRODUCTION AND AIMS: It had been found that dietary AGEs was related to markers of inflammation and oxidative stress in a population of end stage renal disease (ESRD) patients undergoing dialysis . This study was to explore the effects of dietary advanced glycation end products(AGEs) restriction on microinflammation state and intestinal bacterial flora in maintenance hemodialysis(MHD) patients. METHODS: Patients were randomized to normal group(n=10) continuing the same diet, and intervention group taking a dietary AGE restriction for one month(n=10). Blood and stool samples were collected before and after intervention. Highsensitive Creactive protein and interleukin‐6 were detected. The alteration of gut microbiomes were analyzed by bacterial 16S rDNA amplification and DNA pyrosequencing to determine the presence of bacteria. RESULTS: Plasma High‐sensitive C‐reactive protein and interleukin‐6 levels were significantly reduced in dietary AGEs restriction group(p<0.05). The number of Bifidobacterium and Lactobaeillus decreased whereas the number of E. coli and Enterococcus faecalis increased p<0.05) in intervention group. CONCLUSIONS: This study showed significant microbiota differences between two groups inMHDpatients, might provide evidence for reducing uremic toxin from the view of gut microbiota, and play a role in improving lifequality of patient. More research is needed.