Oral cavity-derived stem cells and preclinical models of jaw-bone defects for bone tissue engineering

24Citations
Citations of this article
29Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: Jaw-bone defects caused by various diseases lead to aesthetic and functional complications, which can seriously affect the life quality of patients. Current treatments cannot fully meet the needs of reconstruction of jaw-bone defects. Thus, the research and application of bone tissue engineering are a “hot topic.” As seed cells for engineering of jaw-bone tissue, oral cavity-derived stem cells have been explored and used widely. Models of jaw-bone defect are excellent tools for the study of bone defect repair in vivo. Different types of bone defect repair require different stem cells and bone defect models. This review aimed to better understand the research status of oral and maxillofacial bone regeneration. Main text: Data were gathered from PubMed searches and references from relevant studies using the search phrases “bone” AND (“PDLSC” OR “DPSC” OR “SCAP” OR “GMSC” OR “SHED” OR “DFSC” OR “ABMSC” OR “TGPC”); (“jaw” OR “alveolar”) AND “bone defect.” We screened studies that focus on “bone formation of oral cavity-derived stem cells” and “jaw bone defect models,” and reviewed the advantages and disadvantages of oral cavity-derived stem cells and preclinical model of jaw-bone defect models. Conclusion: The type of cell and animal model should be selected according to the specific research purpose and disease type. This review can provide a foundation for the selection of oral cavity-derived stem cells and defect models in tissue engineering of the jaw bone.

References Powered by Scopus

Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo

3774Citations
N/AReaders
Get full text

Investigation of multipotent postnatal stem cells from human periodontal ligament

2863Citations
N/AReaders
Get full text

Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement

1673Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Advances of calcium phosphate nanoceramics for the osteoinductive potential and mechanistic pathways in maxillofacial bone defect repair

6Citations
N/AReaders
Get full text

SIRT1 activation promotes bone repair by enhancing the coupling of type H vessel formation and osteogenesis

3Citations
N/AReaders
Get full text

Mesenchymal Stromal Cells Derived from Dental Tissues: Immunomodulatory Properties and Clinical Potential

3Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Zhao, J., Zhou, Y. H., Zhao, Y. Q., Gao, Z. R., Ouyang, Z. Y., Ye, Q., … Guo, Y. (2023, December 1). Oral cavity-derived stem cells and preclinical models of jaw-bone defects for bone tissue engineering. Stem Cell Research and Therapy. BioMed Central Ltd. https://doi.org/10.1186/s13287-023-03265-z

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 5

50%

Researcher 3

30%

Professor / Associate Prof. 1

10%

Lecturer / Post doc 1

10%

Readers' Discipline

Tooltip

Medicine and Dentistry 5

50%

Agricultural and Biological Sciences 3

30%

Engineering 1

10%

Materials Science 1

10%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free