Neuropeptide Y (NPY) and its mRNA in discrete brain areas after subchronic administration of neuroleptics

Abstract

Classical (chlorpromazine, haloperidol) and atypical (sulpiride and clozapine) neuroleptics applied for a period of 2 weeks diminished neuropeptide Y (NPY) levels in nucleus accumbens, but not in striatum. These changes were correlated with NPY mRNA level. However, the effect of these neuroleptics on the level of NPY in hypothalamus was different. It is suggested that changes in NPY levels caused by neuroleptics are mediated by dopaminergic D1/D2 receptors.