Recent developments of nanotechnology in tissue adhesives

Abstract

The high incidence of wounds coinciding with the current limitations of available treatments have established a high demand for novel and innovative approaches for wound healing. As a result, tissue adhesives, a promising substitute for traditional wound healing procedures, have lately gained great interest in clinical use. As most of the tissue adhesives are hydrogel-based, however, their behavior is severely weakened by the fragility of hydrogel. Recently, researchers have investigated the potential usages of nanoparticles (NPs) as promising candidates for addressing wound treatment and have managed to discover remarkable, enhanced nanotechnology-based adhesive hydrogels. In this review article, our chief focus is highlighting the latest advances in the usage of nanotechnology in tissue adhesives. In particular, we emphasize two fields in which nanotechnology is employed: the possibility to enhance the mechanical and biochemical properties of tissue adhesives as well as the new functions enabled by NPs, including regenerative ability and accelerated wound healing. We also explore unmet demands and potential future research directions of current technologies, while discussing promising strategies to promote wound-healing procedures.