Synthesis of some monoselenolipoic acid derivatives and their biological evaluation as anticancer agents

Abstract

6-Selenolipoic acid was synthesised from ethyl 6, 8-dichlorooctanoate in a one pot reaction with water as solvent, and was further converted in three steps to 14 N-substituted benzylidene-5-(1, 2-thiaselenolan-3-yl) pentanehydrazides. The compounds exhibited moderate to high anticancer activities, some of them showing activity comparable to that of cisplatin.