P12.02 Demographics and Outcome of Meningioma patients treated in a tertiary care center in the Middle East

Abstract

INTRODUCTION: Meningioma is the most frequently diagnosed intracranial primary brain tumor. Many risk and prognostic factors have been previously reported from various centers in different parts of the world. To our knowledge, data from the Middle East region is lacking. We set to study the risk factors and outcomes of meningioma patients treated in a multidisciplinary tertiary-care center in the Middle East treating patients from the entire region. MATERIAL AND METHODS: Patients with pathologic diagnosis of meningioma from January 2005 to December 2015 at the American Univeristy of Beirut Medical Center (AUBMC) were included. Baseline demographics and risk factors were retrospectively collected and reviewed. Follow up and current disease status were then collected from the patients' charts and updated by a specific questionnaire phone call interviews done by a third party. RESULTS: Two-hundred and seven patients were analyzed. The mean overall survival (OS) and Progression free survival (PFS) for the entire cohort was 81 and 30 months respectively. Patients' area of residence (city VS country side), occupation, alcohol use, oral contraceptive use, family history of meningioma, previous head trauma, exposure to radiation head/brain imaging, cell phone use, and finally their current meningioma's Ki-67 stain were examined in univariate analysis and found not to correlate with survival outcome. On the other hand, high BMI (>25), male gender, intermediate/high grade and subtotal resection were significant predictors of worse OS. Multivariate analysis showed that subtotal resection and intermediate/high grade tumors were significant independent predictors of poor survival. CONCLUSION: In conclusion, our findings coincide with other results reported in the literature from other regions. Complete surgical resection and low-grade disease remain the two most important prognostic factors for patients diagnosed with meningioma.