Synthesis of N-protected spiroamines related to natural products using radical cyclisations

Abstract

The use of radical cyclisations allows direct access to a family of azaspirocyclic ketones, including compounds having the azaspiro[4.4]nonane, and azaspiro[5.5]undecane structures which are found in the alkaloids cephalotaxine and histrionicotoxin. © 1989.