Fibroblast growth factor 21 association with renal function decline in type II diabetes mellitus

Abstract

Serum FGF21 level is strongly associated with the onset of nephropathy in T2D patients and is an independent predictor of loss of renal function in these patient.The study aimed to evaluate the role of FGF21 in early detection of diabetic nephropathy in type 2 diabetes patents. The study included Eighty-eight(88) samples divided in to four groups, three of which included type 2 diabetes patients, according to mircal test (urine albumin / creatinine ratio), they were classified as:22normalbuminuria, 22 microalbuminuria, and 22 macroalbuminuria. The fourth group included 22 apparently healthy subjects with (matched gender and age). The mean ±SD of serum fibroblast growth factor 21 of normoalbuminuria group was (225.00±38.62), microalbuminuria group was (267.78±51.08) and macroalbuminuria group was (230.84±50.33).The comparison results indicated significant increase (p˂0.05) of FGF21 in microalbuminuria group in comparison to that level in normoalbuminurea and macroalbuminuria groups. Also highly significant increase of FGF21 was observed in microalbuminuria group in comparison to that level in control group. We conclude that FGF21 may be a useful marker for early detection of nephropathy.