Association of Mixed Connective Tissue Disease, Sjöegren’s Syndrome and Autoimmune Hepatitis: Report of a Case

Abstract

A 51-year-old female was admitted to the hospital due to liver dysfunction. She had suffered from arthralgia, Raynaud’s phenomenon, dry mouth and dry eyes. Laboratory data showed positive LE cells and anti-RNP. The diagnosis of mixed connective tissue disease (MCTD) was made according to the criteria of the international symposium on MCTD and Antinuclear Antibodies (August 1986, Tokyo). Liver biopsy showed chronic active hepatitis. The results of sialography, lip biopsy and rose-bengal test were compatible with Sjögren’s syndrome (SjS). This is the report of a rare case with MCTD associated with SjS and autoimmune hepatitis. © 1991, The Japanese Society of Internal Medicine. All rights reserved.