Synthesis and biological evaluation of some novel 1, 8-naphthyridine derivatives

Abstract

A series of substituted 1, 8-naphthyridine derivatives was synthesized to be used as cytotoxic and antioxidant agents by applying 1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carbohydrazide (1) as the starting material. Compound 1 was reacted with different reagents to afford the corresponding 3-heterarylcarbonyl-1, 8-naphthyridine derivatives 3-19 which were tested for their in vitro cytotoxicity against Ehrlich Ascites Carcinoma, and antioxidant activity. Compound 15 showed the best cytotoxicity and antioxidant activity.