Medications that cause Prolonged (Q - T) interval on the electrocardiogram (E.C.G) increased risk of developing life-threatening condition

Abstract

Applied clinical work has been carried out and obtained the most important results, the most important threat to human life are heart disorders, especially irregular heart rate and slow side effects caused by some drugs when given and focused on research on the most commonly used therapeutic drugs in our city are anti-irregular heart drugs (Amiadaron), and anti-Depression (amitriptyline), and antibiotic (erythromycin) that increase the QT interval period in ECG (Electrocardiogram) (normal distance: for men less than 450 milliseconds and for women less than 470 msc) these drugs that cause certain doses slow down the heart and press Torsades de pointes (Tdp), ventricular tachycardia) VT Our goal is to remove the risk from people where there are more than 100 types of drugs that prolong QT for the longest period and cause the most serious torsades. de pointes of different forms which lead to sudden death, fainting possibilities, episodes of loss of consciousness, chest pain, shortness of breath, we worked through the monitoring of analyzes and (ECG, Echo and effort, radiation and patient history of patients and risk factors and physiological changes that occur and monitor patients carefully and cautiously Prevention of side effects will avoid the patient reaching the ventricular fibrillation (VF) threatened with sudden death, and we selected patients greater than > 40 years as follows: (total patients is 340 patients 200 men and 140 women) and for a period (9 months 2018-2019) we have divided patients in terms of age and sediment Factor (risk factors) More than 40 years (age 40-55 years Rsik 1) and (Rsik 2 of 55-65 years) and (65 years and above Rsik 3) are divided into three spheres of the first Group: Anti-arrhythmic (Amiadaron). Group II: Anti-depressants Anti-depressants (Amitriptyline) Group III: Anti-biotic (erythromycin) So the result was: - ∗ Group I: men 52 - women 40): Amiadaron used cautiously in the form of Oral (mouth) tablets 200 Mg 2 times a day depending on the patient's condition and stability or emergency and ECG monitoring) and electrolyte analysis Risk 1 age of 40-55 years rarely seen slowing the heart heart block (cut the electrical conductivity of the heart) and the length of the QT less than 500 msc and the rate (360 - 480 msc) The amine did not occur problem, either cases who take high dose or in the world Concentrated infusion (Nutrient infusion), ie, those with the second and third rusks and risk factors The length of the Q-T period is more than 500 msc, who are at risk of seizures, especially the electrolyte disorder associated with them and their lives are threatened with death by 9% in intensive care. By controlling the dosage that preserves the patient's life, ∗ Group II: Antidepressants amitriptyline we used the dose (25-100 mg) per day⋯ the first 6 days of treatment until after 30 days and control QT in the dose less than 100 mg the result is there The length of the QT is confined between (360-480 msc) less than m 500 msc or 96% Nothing happened to be endangered and without reliable electrolyte disturbances and is safe for Risk 1, Risk 2, 3 If the dose is greater than 100 mg and the electrolyte disturbance, QT length of more than 500 msc is threatened by death SCD. tdp, 6% confined between (1.04 - 6.12) The drug should be discontinued immediately⋯ ∗ Group III: erythromycin at a dose (1000 mg) by mouth and by infusion (intravenous infusion) Patients Risk 1. No risk change (360-450) Either in the case of giving the patient or the presence of allergies in patients, ectopic disorders (migrating heartbeat) and irregular heart, especially in the The high QT is more than 1500 mg and the length of QT is greater than 500 msc. The VT'. Torside de Point Tdp. So not to exceed the dose to preserve the safety of the patient. And the safe dose that does not put the patient at risk of death and save their lives.