From your kidneys to your eyes: lessons from computational kidney models

Abstract

Purpose: The purpose of this review is to describe computational models that have been developed for studying kidney function and how these models may be adapted to study the eyes. Methods: We derive equations for modeling solute and water transport across epithelial cell membranes in the kidney. These equations describe mass conservation, as well membrane transport via cotransporters, exchangers, and primary active transport. Results: We describe how computational models of renal transport have been applied to investigate kidney function in physiological and pathophysiological conditions. Conclusion: The computational models herein described for the kidney may be adapted to study ocular functions and dysfunction.