Chemical and Pharmaceutical Studies on Medicinal Plants in Paraguay. I. Isolation and Identification of Lens Aldose Reductase Inhibitor from “Tapecué,” Acanthospermum australe O.K.

Abstract

The Et0H extract of “Tapecue,” Acanthospermum australe, was found to have a potent inhibitory activity towards rat lens aldose reductase (AR). From the active fraction of the extract, 5, 7, 4’-trihydroxy-3, 6-dimethoxyflavone was isolated. It was found to have higher activity (IC50 = 1 x 10-7m) than quercitrin, which is a known inhibitor of AR (IC50 = 1.8 x 10-6m in our bioassay). © 1987, The Pharmaceutical Society of Japan. All rights reserved.