Abstract
Background: The NEDD8 protein and neddylation levels in cells are modulated by NUB1L. Results: NUB1L down-regulated the NEDD8 levels by directly interacting with NEDD8 and P97. Conclusion: NUB1L joins to the P97UFD1/NPL4 complex and promotes transfer of NEDD8 to proteasome for degradation. Significance: This study provides a molecular mechanism for modulation of neddylation. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.
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CITATION STYLE
Liu, S., Yang, H., Zhao, J., Zhang, Y. H., Song, A. X., & Hu, H. Y. (2013). NEDD8 ultimate buster-1 long (NUB1L) protein promotes transfer of NEDD8 to proteasome for degradation through the P97UFD1/NPL4 complex. Journal of Biological Chemistry, 288(43), 31339–31349. https://doi.org/10.1074/jbc.M113.484816
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