C-Reactive Protein and Matrix Metalloproteinase-7 in Preterm Premature Rupture of Membranes (PPROM) and Premature Rupture of Membranes (PROM)

Abstract

Objective: To determine the difference in qualitative serum CRP and MMP-7 levels between PROM and PPROM. Methods: Research with a case-control design with premature rupture of membranes in term pregnancy as a control group and preterm pregnancy as a case group conducted in the delivery room of the Regional General Hospital dr. Zainoel Abidin Banda Aceh starting from January 2020. Total number of each group as many as 30 samples that met the inclusion and exclusion criteria by taking venous blood samples to check the levels of qualitative CRP serum and levels of the Metalloproteinase-7 Matrix (MMP-7). Statistical tests for categorical - numerical data groups were tested using independent sample t-test and categorical - categorical data groups were tested using Chi-Square test. Results: A total of 60 samples with 30 PPROM and 30 PROM mothers. There was no statistically significant difference in the qualitative CRP serum result in PROM patients with term and preterm pregnancies. On MMP-7 examination, the mean MMP-7 level of preterm PROM mothers was higher than at term PROM, which was 5.28 mg / L and there was a significant relationship between MMP-7 and qualitative CRP in PROM patients with term pregnancy (p <0.05). Conclusion: There is no significant difference in the value of qualitative CRP and MMP-7 between PPROM and PROM. However, there was a significant association between qualitative serum CRP and plasma MMP-7 in PROM.