Evidence-Based Choice of Conditioning Regimen for Hematopoietic Stem Cell Transplantation (HSCT) in Acute Leukemia: The Italian Cellular Therapy and Stem Cell Transplant Group (GITMO) Guidelines

Abstract

BACKGROUND Conditioning regimens for acute myeloid (AML) and lymphoid (ALL) leukemia include a wide set of chemo-radiotherapy combinations capable of inducing a decline of bone marrow activity and thus favoring allogeneic stem cell engraftment and preventing leukemia relapse. Hematopoietic stem cell transplantation (HSCT) conditioning schedules include alkylating, non-alkylating drugs and, in some cases, total body irradiation (TBI). Drugs and/or TBI dose identify the intensity of conditioning regimen. Excessive heterogeneity of the clinical practices may limit the auditing and the correct interpretation of the