An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases

Abstract

(Figure Presented) Seeing is believing: A fluorescent probe for monitoring the activity of dual-specific protein tyrosine phosphatases (PTPs) has been developed (see scheme). Selective enzymatic hydrolysis and subsequent intramolecular cyclization results in a highly fluorescent iminocoumarin fluorophore. © 2010 Wiley-VCH Verlag GmbH&Co. KGaA.