Chemical structure of an acylated oleanane-type triterpene oligoglycoside and anti-inflammatory constituents from the flower buds of Camellia sinensis

Abstract

A new acylated oleanane-type triterpene oligoglycoside, floratheasaponin K (1), was isolated together with 11 known compounds including floratheasaponins D (2)-G (5), and I (6), chakasaponin V (7), and assamsaponin E (8) from the flower buds of Camellia sinensis cultivated in India. The chemical structure of floratheasaponin K (1) was elucidated on the basis of chemical and physicochemical evidence. In addition, chakasaponins V (7) and I (13) significantly inhibited nitric oxide (NO) production in lipopolysaccharide-(LPS) activated RAW264.7 cells without cytotoxicity.