Body Weight Management in Healthy Humans Using Low-Sugar and High-Dietary Fiber Noodles: A Single Group Pre-Post Trial

Abstract

Background. The recommendation of the low-carbohydrate diet by the American Diabetes Association (2013) has popularized its use as a nutritional treatment. Previously, we evaluated the effects of a novel strategy to reduce dietary intake based on low-sugar, high-dietary fiber noodles (LS-HDFNs) composed of okara and konjac on blood glucose levels in healthy animals, animal models of type 2 diabetes, and healthy humans (the single meal test). In this study, a single group pre-post trial for 28 days administration was carried out to investigate the body weight management in healthy humans using LS-HDFNs. Methods. Nine healthy subjects were requested to eat LS-HDFNs once (180 g) daily for 28 days. Physical characteristics and blood biochemical parameters were measured before (0 day) and after (28 days) the consumption of the noodles. Qualitative analysis of compounds in the noodles was investigated by the HPLC system and the UPLC/qTOF-MS system. Results. The LS-HDFNs group did not exhibit any complications or adverse effects. Furthermore, the body weights, body fat percentage, total cholesterol, and low-density lipoprotein cholesterol were significantly reduced after 28 days of LS-HDFNs consumption. Some isoflavones, amino acids, peptides, and phospholipids were contained in the LS-HDFNs. Conclusion. As per our knowledge, this is the first study of the usefulness of consumption of LS-HDFNs for 28 days for body weight management in healthy humans. LS-HDFNs may be useful for body weight management. This trial is registered with number 2020002, registered on 2nd March 2020.