Effect of hemodialysis on some biochemical parameters in diabetic nephropathy patients

Abstract

Diabetes mellitus is a worldwide epidemic and is associated with long-term damage and causes dysfunction of several organs like kidney leading to diabetic nephropathy. This study was designed to evaluate some biochemical aspects. This study was conducted on 95 patients which included (35) HD patients with diabetes and (35) HD patients without diabetes and (25) Type 2 diabetes mellitus patients, who attended at Ramadi General Hospital. For the purpose of comparison, (25) samples as control. Several tests were performed such as FSB, urea, creatinine, glomerular filtration rate (GFR), albumin, sodium ion, calcium ion, Phosphorus ion, potassium ion and magnesium ion were calculated. This study showed the level of urea and creatinine were a significant increase in HD patients with diabetes(128.29±22.59 and 7.1±1.76) mg/dl respectively, and HD patients without diabetes were (125.74±23.28 and 6.80±2.71) mg/dl respectively. The levels of Na+ and Ca++ were decrease in HD patients with diabetes (137.6±4.8 mmol/L and 6.72±1.76mg/dl) respectively. The levels of P, K+ and Mg++ were a significant increase in HD patients without diabetes(6.26±0.84 mg/dl, 5.52±0.61 mmol/L and 2.2±0.13mg/dl) respectively. The urea, creatinine and GFR are simple and useful biomarkers which can serve as predictor tests for assessing kidney functions in diabetic patients.