Syntesis and antibacterial activity of dibenzylidene-cyclohexanone

Abstract

Dibenzylidene-cyclohexanone was synthesized by reacting aromatic aldehydes with cyclohexanone in the acidic condition through the carbonyl condensation reaction. The antibacterial activity was tested by using microdilution method against K. pneumonia, E. coli, S. aureus, B. subtilis and E. faecalis. The isolated products were obtained as pure curcumin analogs with moderate to high yield. The antibacterial assay showed that 2,6-bis-(3’-hydroxybenzylidene)-cyclohexanone gave MIC and MBC at 50 µg/mL in E. coli, S. aureus, and E. faecalis. Moreover, it showed that the percentage inhibition of B. subtilis was around 54 % at a concentration of 25 µg/mL. Among all the tested compounds, A146 showed better activity against all those bacteria while none showed activity against K. pneumonia. A111 was obtained as the compound with the highest yield and A146 was the most potent compound. While A102 was the most potent compound according to the docking study.