The pharmacometrician's dilemma: the tension between mechanistic and empirical approaches in mathematical modelling and simulation – a continuation of the age-old dispute between rationalism and empiricism?

Bies, R., Cook, S., & Duffull, S. (2016). The pharmacometrician’s dilemma: the tension between mechanistic and empirical approaches in mathematical modelling and simulation – a continuation of the age-old dispute between rationalism and empiricism? British Journal of Clinical Pharmacology. Blackwell Publishing Ltd. https://doi.org/10.1111/bcp.13040