[The changes in the activity of tripeptidyl peptidase II in experimental atherosclerosis and hypertension].

Abstract

The changes in the activity of intracellular proteolytic systems are important mechanisms in the damage of blood vessels walls and arterial hypertension. Tripeptidyl peptidase II (TPP II) is one of the giant intracellular protease that is still poorly known. It fulfils hydrolysis of peptides, coming from proteasomal proteolysis. Modeling of cholesterol atherosclerosis in rabbits (1% of cholesterol in diet for 2 month) results in the significant decrease of TPP II activity in aorta tissues. This diet in spontaneously hypertensive rats (SHR) leads to a decrease of TPP II activity in aorta tissues (on 50%, P < 0.05) but has no influence on the activity of TPP II in Wistar rats. Application of Quercetin prevents the inhibition of TPP II activity in aorta tissues of rabbits and SHR at experimental hypercholesterolemia. The data received show that changes in the activity of TPP II play an important role in pathogenesis of blood vessels wall in atherosclerosis and arterial hypertension.